|
KMID : 0043320100330060875
|
|
Archives of Pharmacal Research
2010 Volume.33 No. 6 p.875 ~ p.880
|
|
|
Constituents of the Flowers of Platycodon grandiflorum with Inhibitory Activity on Advanced Glycation End Products and Rat Lens Aldose Reductase In Vitro
|
|
Kim Jin-Sook
Jang Dae-Sik
Lee Yun-Mi
Jeong Il-Ha
|
|
|
Abstract
|
|
|
|
In an ongoing project directed toward the discovery of novel treatments for diabetic complications from traditional herbal medicines, fifteen compounds, apigenin (1), apigenin-7-O-β-D-glucopyranoside (2), apigenin-7-O-(6’’-O-acetyl)-β-D-glucopyranoside (3), luteolin (4), luteolin-7-O-β-D-glucopyranoside (5), luteolin-7-O-(6’’-O-acetyl)-β-D-glucopyranoside (6), isorhamnetin-3-Oneohesperidoside (7), 4-O-caffeoylquinic acid (8), chlorogenic acid methyl ester (9), 4-O-β-Dglucopyranosylcaffeic acid (10), lobetyolin (11), cordifolioidyne C (12), isomultiflorenyl acetate (13), β-sitosterol glucoside (14), and α-spinosterol (15), were isolated from an EtOAc-soluble fraction of the flowers of Platycodon grandiflorum (balloonflower; Campanulaceae). The structures of the compounds were identified by physical and spectroscopic methods, as well as by comparison of their data with literature values. All the isolates were evaluated in vitro for inhibitory activity on the formation of advanced glycation end products and rat lens aldose reductase.
|
|
|
KEYWORD
|
|
|
Platycodon grandiflorum, Campanulaceae, Advanced glycation end products (AGEs), Rat lens aldose reductase (RLAR), Diabetic complications
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|